| Definition: A control interaction in which a physical entity modulates a catalysis interaction. Biologically, most modulation interactions describe an interaction in which a small molecule alters the ability of an enzyme to catalyze a specific reaction. Instances of this class describe a pairing between a modulating entity and a catalysis interaction. Comment: A separate modulation instance should be created for each different catalysis instance that a physical entity may modulate and for each different physical entity that may modulate a catalysis instance. A typical modulation instance has a small molecule as the controller entity and a catalysis instance as the controlled entity. Examples: Allosteric activation and competitive inhibition of an enzyme’s ability to catalyze a specific reaction. |
| •owl:Thing |
| •entity |
| •interaction |
| •physicalInteraction |
| •control |
| •modulation |
| control |
| CONTROLLER MAX 1 |
| CONTROLLED ONLY catalysis |
Class(modulation partial control
restriction(CONTROLLER maxCardinality(1))
restriction(CONTROLLED allValuesFrom(catalysis)))
DisjointClasses(modulation catalysis)