org.biopax.paxtools.model.level3
Enum ControlType

java.lang.Object
  java.lang.Enum<ControlType>
      org.biopax.paxtools.model.level3.ControlType

All Implemented Interfaces:

java.io.Serializable, java.lang.Comparable<ControlType>

public enum ControlType
extends java.lang.Enum<ControlType>

Defines the nature of the control relationship between the controller and the controlled entities.

Enum Constant Summary

ACTIVATION
General activation.

ACTIVATION_ALLOSTERIC
Allosteric activators increase the specified enzyme activity by binding reversibly to the enzyme and inducing a conformational change that increases the affinity of the enzyme to its substrates without affecting its VMAX.

ACTIVATION_NONALLOSTERIC
Nonallosteric activators increase the specified enzyme activity by means other than allosteric.

ACTIVATION_UNKMECH
Deprecated. LEVEL 1 workaround

INHIBITION
General inhibition.

INHIBITION_ALLOSTERIC
Allosteric inhibitors decrease the specified enzyme activity by binding reversibly to the enzyme and inducing a conformational change that decreases the affinity of the enzyme to its substrates without affecting its VMAX.

INHIBITION_COMPETITIVE
Competitive inhibitors are compounds that competitively inhibit the specified enzyme activity by binding reversibly to the enzyme and preventing the substrate from binding.

INHIBITION_IRREVERSIBLE
Irreversible inhibitors are compounds that irreversibly inhibit the specified enzyme activity by binding to the enzyme and dissociating so slowly that it is considered irreversible.

INHIBITION_NONCOMPETITIVE
Noncompetitive inhibitors are compounds that noncompetitively inhibit the specified enzyme by binding reversibly to both the free enzyme and to the enzyme-substrate complex.

INHIBITION_OTHER
Compounds that inhibit the specified enzyme activity by a mechanism that has been characterized, but that cannot be clearly classified as irreversible, competitive, noncompetitive, uncompetitive, or allosteric.

INHIBITION_UNCOMPETITIVE
Uncompetitive inhibitors are compounds that uncompetitively inhibit the specified enzyme activity by binding reversibly to the enzyme-substrate complex but not to the enzyme alone.

INHIBITION_UNKMECH
Deprecated. LEVEL 1 workaround

Method Summary

static ControlType	valueOf(java.lang.String name) Returns the enum constant of this type with the specified name.
static ControlType[]	values() Returns an array containing the constants of this enum type, in the order they are declared.

Methods inherited from class java.lang.Enum

clone, compareTo, equals, finalize, getDeclaringClass, hashCode, name, ordinal, toString, valueOf

Methods inherited from class java.lang.Object

getClass, notify, notifyAll, wait, wait, wait

Enum Constant Detail

ACTIVATION

public static final ControlType ACTIVATION

General activation. Compounds that activate the specified enzyme activity by an unknown mechanism. The mechanism is defined as unknown, because either the mechanism has yet to be elucidated in the experimental literature, or the paper(s) curated thus far do not define the mechanism, and a full literature search has yet to be performed.

INHIBITION

public static final ControlType INHIBITION

General inhibition. Compounds that inhibit the specified enzyme activity by an unknown mechanism. The mechanism is defined as unknown, because either the mechanism has yet to be elucidated in the experimental literature, or the paper(s) curated thus far do not define the mechanism, and a full literature search has yet to be performed.

ACTIVATION_UNKMECH

public static final ControlType ACTIVATION_UNKMECH

Deprecated. LEVEL 1 workaround

INHIBITION_UNKMECH

public static final ControlType INHIBITION_UNKMECH

Deprecated. LEVEL 1 workaround

INHIBITION_ALLOSTERIC

public static final ControlType INHIBITION_ALLOSTERIC

Allosteric inhibitors decrease the specified enzyme activity by binding reversibly to the enzyme and inducing a conformational change that decreases the affinity of the enzyme to its substrates without affecting its VMAX. Allosteric inhibitors can be competitive or noncompetitive inhibitors, therefore, those inhibition categories can be used in conjunction with this category.

INHIBITION_COMPETITIVE

public static final ControlType INHIBITION_COMPETITIVE

Competitive inhibitors are compounds that competitively inhibit the specified enzyme activity by binding reversibly to the enzyme and preventing the substrate from binding. Binding of the inhibitor and substrate are mutually exclusive because it is assumed that the inhibitor and substrate can both bind only to the free enzyme. A competitive inhibitor can either bind to the active site of the enzyme, directly excluding the substrate from binding there, or it can bind to another site on the enzyme, altering the conformation of the enzyme such that the substrate can not bind to the active site.

INHIBITION_IRREVERSIBLE

public static final ControlType INHIBITION_IRREVERSIBLE

Irreversible inhibitors are compounds that irreversibly inhibit the specified enzyme activity by binding to the enzyme and dissociating so slowly that it is considered irreversible. For example, alkylating agents, such as iodoacetamide, irreversibly inhibit the catalytic activity of some enzymes by modifying cysteine side chains.

INHIBITION_NONCOMPETITIVE

public static final ControlType INHIBITION_NONCOMPETITIVE

Noncompetitive inhibitors are compounds that noncompetitively inhibit the specified enzyme by binding reversibly to both the free enzyme and to the enzyme-substrate complex. The inhibitor and substrate may be bound to the enzyme simultaneously and do not exclude each other. However, only the enzyme-substrate complex (not the enzyme-substrate-inhibitor complex) is catalytically active.

INHIBITION_OTHER

public static final ControlType INHIBITION_OTHER

Compounds that inhibit the specified enzyme activity by a mechanism that has been characterized, but that cannot be clearly classified as irreversible, competitive, noncompetitive, uncompetitive, or allosteric.

INHIBITION_UNCOMPETITIVE

public static final ControlType INHIBITION_UNCOMPETITIVE

Uncompetitive inhibitors are compounds that uncompetitively inhibit the specified enzyme activity by binding reversibly to the enzyme-substrate complex but not to the enzyme alone.

ACTIVATION_NONALLOSTERIC

public static final ControlType ACTIVATION_NONALLOSTERIC

Nonallosteric activators increase the specified enzyme activity by means other than allosteric.

ACTIVATION_ALLOSTERIC

public static final ControlType ACTIVATION_ALLOSTERIC

Allosteric activators increase the specified enzyme activity by binding reversibly to the enzyme and inducing a conformational change that increases the affinity of the enzyme to its substrates without affecting its VMAX.

Method Detail

values

public static ControlType[] values()

Returns an array containing the constants of this enum type, in the order they are declared. This method may be used to iterate over the constants as follows:

for (ControlType c : ControlType.values())
    System.out.println(c);

Returns:

an array containing the constants of this enum type, in the order they are declared

valueOf

public static ControlType valueOf(java.lang.String name)

Returns the enum constant of this type with the specified name. The string must match exactly an identifier used to declare an enum constant in this type. (Extraneous whitespace characters are not permitted.)

Parameters:

name - the name of the enum constant to be returned.

Returns:

the enum constant with the specified name

Throws:

java.lang.IllegalArgumentException - if this enum type has no constant with the specified name

java.lang.NullPointerException - if the argument is null